Aprepitant impurity 58 CAS CATO-C4X-114158
| CAS No. | CATO-C4X-114158 |
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Aprepitant impurity 58 (C23H22F7N4O6PC7H17NO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Aprepitant impurity 58 (CAS CATO-C4X-114158) is a certified pharmaceutical impurity reference standard with the molecular formula C23H22F7N4O6PC7H17NO5 and a molecular weight of 809.63 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprepitant impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22F7N4O6P C7H17NO5 |
| Molecular Weight | 809.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Isavuconazole Impurity 79 (CAS 483340-20-1)
- Dexmedetomidine Impurity 39 (CAS CATO-C4X-123039)
- Bilastine impurity 89 (CAS CATO-C4X-225389)
- 2-(6,6-Dimethyl-1,4-dioxan-2-yl)acetic acid (CAS 2138052-20-5)
- 2,3,5,6-Tetrafluorophenol dihydrate (CAS 250261-32-6)
- (S)-3-benzyl-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid (CAS 170838-87-6)
- (2-(Benzylamino)phenyl)methanol (CAS 1722-07-2)
- 2-Phenoxypropanal (CAS 52687-81-7)
- Ethyl 3-(2-bromophenyl)-1H-1,2,4-triazole-5-carboxylate (CAS 1281498-55-2)
- Erythropoietin Mimetic Peptide Sequence 20 (CAS 203397-62-0)
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