Aprepitant impurity 63 CAS CATO-C4X-114163
| CAS No. | CATO-C4X-114163 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Aprepitant impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Aprepitant impurity 63 (CAS CATO-C4X-114163), a pharmacopoeial impurity reference standard (molecular formula C20H18F7NO2HCl, MW 473.81 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Aprepitant impurity 63 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 473.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 HCl |
| Molecular Weight | 473.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Cabazitaxel Impurity 26 (CAS 144790-01-2)
- Dabigatran Impurity 121 (CAS CATO-C4X-1089121)
- Prednisolone impurity 67 (CAS 20380-17-0)
- (4-Methyl-6-(pyrrolidin-1-yl)pyridin-3-yl)(phenyl)methanol (CAS 1355215-28-9)
- (1-Methyl-3-phenyl-5-((3-(trifluoromethyl)phenyl)thio)-1H-pyrazol-4-yl)methyl 3,5-bis(trifluoromethyl)benzoate (CAS 318497-74-4)
- 2-Methyl-5-(2-trifluoromethylbenzoyl)pyridine (CAS 1187166-87-5)
- (4-Amino-2-chloro-phenyl)-carbamic acid tert-butyl ester (CAS 342882-96-6)
- 1-Nonyl-3-phenylcyclopent-3-enamine (CAS 862367-66-6)
- Lithium polysilicate solution (CAS 12627-14-4)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com