Halometasone impurity 14 CAS CATO-C4X-144614
| CAS No. | CATO-C4X-144614 |
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Halometasone impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Halometasone impurity 14 (CAS CATO-C4X-144614, C22H28ClFO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Halometasone impurity 14 (C22H28ClFO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 426.91 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H28ClFO5 |
| Molecular Weight | 426.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Halometasone Standards
- Halometasone Impurity 3 (CAS 67212-85-5)
- Halometasone Impurity 9 (CAS CATO-C4X-14469)
- Halometasone Impurity N2 (CAS 80157-55-7)
- Halometasone impurity 15 (CAS CATO-C4X-144615)
- Halometasone impurity 17 (CAS 35540-75-1)
- Halometasone Impurity 4 (CAS CATO-C4X-14464)
- Halometasone Impurity 67 (CAS CATO-C4X-14467)
- Halometasone (CAS 50629-82-8)
Recommended Standards
- Darolutamide impurity 7 (CAS CATO-C4X-31067)
- Fluticasone Impurity 101 (CAS CATO-C4X-1650101)
- (Z)-Methyl 2-(1-(2-chlorophenyl)-4-((3-(dimethylamino)phenyl)(methylamino)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetate (CAS 1820587-57-2)
- Fluticasone Impurity 49 (CAS CATO-C4X-165049)
- Nintedanib Impurity 36 (CAS 1160293-27-5)
- Carbocisteine Impurity 11 (CAS 25515-73-5)
- Etrasimod Impurity 77 (CAS CATO-C4X-321477)
- Ethyl 2-(2-methoxy-5-nitrophenoxy)acetate (CAS 162155-38-6)
- m-PEG5-azide (CAS 1202681-04-6)
- 3-(4-Ethylphenyl)-1-(1H-imidazol-4-yl)propan-1-ol (CAS 755705-95-4)
- Methapyrilene Hydrochloride (CAS 135-23-9)
- 2-Iodobenzo[d]oxazole (CAS 102675-92-3)
- 2,6-Difluoro-N-hydroxybenzimidoyl chloride (CAS 118591-69-8)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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