Riociguat Impurity 42 HCl CAS CATO-C4X-174942
| CAS No. | CATO-C4X-174942 |
| Molecular Formula | C14H12FN5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Riociguat Impurity 42 HCl (CAS CATO-C4X-174942), a pharmacopoeial impurity reference standard (molecular formula C14H12FN5HCl, MW 305.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Riociguat Impurity 42 HCl (C14H12FN5HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Riociguat Impurity 42 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12FN5 HCl |
| Molecular Weight | 305.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Riociguat Standards
- Riociguat-13C-d3 (CAS 1304478-43-0)
- Riociguat Impurity 2 (CAS 1361569-10-9)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat Impurity 1 (CAS 1702271-98-4)
- Riociguat Impurity N10 (CAS 2101651-50-5)
- Riociguat Impurity N3 (CAS 2512205-25-1)
- Riociguat Impurity 30 (CAS 2518331-19-4)
Recommended Standards
- Avibactam Impurity 81 (CAS CATO-C4X-134881)
- Granisetron EP Impurity A HCL (CAS 127472-42-8（free base）)
- Iguratimod Impurity 11 (CAS 149456-98-4)
- 2,9-Diphenylanthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone (CAS 128-65-4)
- (E)-N'-(4-cyano-1-methyl-1H-pyrazol-5-yl)-N-hydroxyformimidamide (CAS 1001629-50-0)
- (3Z)-N-(2,4-Difluorophenyl)-3-{[(4-nitrophenyl)methoxy]imino}propanamide (CAS 320418-05-1)
- Ethyl 7-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 503591-61-5)
- Bis(4-(allyloxy)phenyl)methanone (CAS 136074-26-5)
- Epinastine Impurity 8 (CAS CATO-C4X-18408)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com