Avatrombopag Impurity 74 CAS CATO-C4X-223474
| CAS No. | CATO-C4X-223474 |
| Molecular Formula | C14H17ClN2O4 |
| Molecular Weight | 312.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Avatrombopag Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Avatrombopag Impurity 74 (CAS CATO-C4X-223474) is a certified pharmaceutical impurity reference standard with the molecular formula C14H17ClN2O4 and a molecular weight of 312.75 g/mol.
Avatrombopag Impurity 74 (C14H17ClN2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H17ClN2O4 |
| Molecular Weight | 312.75 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 4 (CAS 931395-73-2)
- Avatrombopag Impurity 50 (CAS CATO-C4X-223450)
- Avatrombopag Impurity 72 (CAS CATO-C4X-223472)
- Avatrombopag Impurity 116 (CAS CATO-C4X-2234116)
- Avatrombopag impurity 125 (CAS CATO-C4X-2234125)
- Avatrombopag Impurity 49 (CAS CATO-C4X-223449)
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
Recommended Standards
- 1,1'-(2-Chloropropane-1,3-diyl)bis(1H-benzo[d][1,2,3]triazole) (CAS 187095-23-4)
- Estazolam Impurity 5 (CAS CATO-C4X-19225)
- (S)-6-Chloro-2-(2-fluoroethyl)-5-methoxy-2-(3-oxobutyl)-2,3-dihydro-1H-inden-1-one (CAS 945726-52-3)
- Erlotinib Impurity 13 (CAS 183322-18-1)
- Azlocillin Oxide Impurity (CAS CATO-C4X-23201)
- Icaritin Impurity 7 (CAS 60-82-2)
- Dutasteride EP Impurity G (CAS 1430804-85-5)
- Methyl 2-amino-3-(hydroxymethyl)benzoate (CAS 253120-48-8)
- (3R)-4-(Benzyloxy)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid (CAS 1233495-08-3)
- 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-methoxyphenyl)benzamide (CAS 338392-21-5)
- (2-Phenylmorpholino)(4-propylphenyl)methanone (CAS 953984-20-8)
- 8-Azabicyclo[3.2.1]octane (CAS 280-05-7)
- Roflumilast Impurity 17 (CAS 91872-02-5)
- Fibrinopeptide B (human) (CAS 36204-23-6)
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