Avatrombopag impurity 125 CAS CATO-C4X-2234125
| CAS No. | CATO-C4X-2234125 |
| Molecular Formula | C11H13ClN4S2 |
| Molecular Weight | 300.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avatrombopag impurity 125.
As a process- or degradation-related impurity, Avatrombopag impurity 125 (CAS CATO-C4X-2234125, C11H13ClN4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Avatrombopag impurity 125 (C11H13ClN4S2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13ClN4S2 |
| Molecular Weight | 300.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 38 (CAS 2161380-87-4)
- Avatrombopag Impurity 43 (CAS 1268118-96-2)
- Avatrombopag Impurity 144 (CAS CATO-C4X-2234144)
- Avatrombopag Impurity 72 (CAS CATO-C4X-223472)
- Avatrombopag Impurity 50 (CAS CATO-C4X-223450)
- Avatrombopag Impurity 4 (CAS 931395-73-2)
Recommended Standards
- Clomacran (CAS 5310-55-4)
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- Prasugrel Impurity 37 (CAS 239466-43-4（Free Base）)
- Glimepiride Impurity 10 (CAS 600177-94-4)
- Dapagliflozin Impurity 20 (CAS 2169998-23-4)
- 2-[4-(4-Methoxybenzoyl)-1H-1,2,3-triazol-1-yl]-4-methyl-6-(trifluoromethyl)pyrimidine (CAS 861207-84-3)
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- 5-Chloro-3-(2-methoxyethoxy)thiophene-2-carboxylic acid (CAS 1708250-98-9)
- 5-(2-Chloro-4-pyrimidinyl)-2-hydroxybenzonitrile (CAS 1292317-53-3)
- 1-(4-Bromophenyl)propane-1-thiol (CAS 1039964-57-2)
- 1-(2-(2-Fluorophenoxy)acetyl)piperidine-4-carboxylic acid (CAS 1054043-50-3)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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