Avatrombopag Impurity 72 CAS CATO-C4X-223472
| CAS No. | CATO-C4X-223472 |
| Molecular Formula | C14H15ClN2O4 |
| Molecular Weight | 310.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Avatrombopag Impurity 72 (CAS CATO-C4X-223472, C14H15ClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Avatrombopag Impurity 72 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 310.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avatrombopag Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H15ClN2O4 |
| Molecular Weight | 310.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 50 (CAS CATO-C4X-223450)
- Avatrombopag Impurity 4 (CAS 931395-73-2)
- Avatrombopag Impurity 74 (CAS CATO-C4X-223474)
- Avatrombopag Impurity 116 (CAS CATO-C4X-2234116)
- Avatrombopag impurity 125 (CAS CATO-C4X-2234125)
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 38 (CAS 2161380-87-4)
Recommended Standards
- Ethyl N-[2-acetyl-3-(4-chloroanilino)acryloyl]carbamate (CAS 321432-23-9)
- Icotinib Impurity 5 (CAS 1204313-58-5)
- Ethyl 5-{[(2-chlorophenyl)formamido]methyl}-4,5-dihydro-1,2-oxazole-3-carboxylate (CAS 339100-99-1)
- Ethyl 6-chloro-8-morpholinoimidazo[1,2-b]pyridazine-2-carboxylate (CAS 1639891-84-1)
- Apixaban Impurity 64 (CAS 1039914-85-6)
- Tizanidine Impurity 66 (CAS 67357-53-3)
- Ozagrel Impurity 6 (CAS 143945-86-2)
- 3-(1,2,4-Oxadiazol-5-yl)piperidine hydrochloride (CAS 1803586-45-9)
- 1-(Trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (CAS 112037-78-2)
- 3-Formyl-2,4,6-trimethylbenzyl acetate (CAS 137380-48-4)
- 5-Acetylpyridine-2-carboxaldehyde (CAS 871366-23-3)
- 7-Chloro-1-isopropyl-1H-pyrazolo[4,3-d]pyrimidine (CAS 923283-49-2)
- (7-Hydroxy-2-methylpyrazolo[1,5-a]pyrimidin-6-yl)(phenyl)methanone (CAS 1355182-75-0)
- Hexapeptide-9 (CAS 1228371-11-6)
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