Avatrombopag Impurity 50 CAS CATO-C4X-223450
| CAS No. | CATO-C4X-223450 |
| Molecular Formula | C7H4BrClN2OS2 |
| Molecular Weight | 311.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Avatrombopag Impurity 50 (CAS CATO-C4X-223450, C7H4BrClN2OS2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Avatrombopag Impurity 50 (C7H4BrClN2OS2) contains an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 311.61 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4BrClN2OS2 |
| Molecular Weight | 311.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 72 (CAS CATO-C4X-223472)
- Avatrombopag Impurity 4 (CAS 931395-73-2)
- Avatrombopag Impurity 74 (CAS CATO-C4X-223474)
- Avatrombopag Impurity 116 (CAS CATO-C4X-2234116)
- Avatrombopag impurity 125 (CAS CATO-C4X-2234125)
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 38 (CAS 2161380-87-4)
Recommended Standards
- (3-Chloro-4-(3-(4-methylpiperidin-1-yl)propoxy)phenyl)boronic acid (CAS 1704081-78-6)
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- 3-Chloro-2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1387634-81-2)
- 2-Bromo-4-tert-butylbenzenesulfonyl chloride (CAS 99057-15-5)
- Benzhexol Impurity 10 (CAS 833-86-3)
- Hydrocortisone EP Impurity L (CAS 641-77-0)
- Halometasone impurity 15 (CAS CATO-C4X-144615)
- 6-iodopyridine-3-carboxylic acid (CAS 13054-02-9)
- N-(5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)cyclohexanamine (CAS 2096340-23-5)
- 1-(3-Bromopropoxy)-2,3-dichlorobenzene (CAS 1009621-74-2)
- 2-Methyl-4-(tetrahydrofuran-2-yl)butanoic acid (CAS 857789-92-5)
- 2-(1,1-Dimethylethoxy)ethanol (CAS 7580-85-0)
- (4S,5R)-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)dihydrofuran-2(3H)-one (CAS 1173700-22-5)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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