Avatrombopag Impurity 38 CAS 2161380-87-4
| CAS No. | 2161380-87-4 |
| Molecular Formula | C7H4BrClN2S2 |
| Molecular Weight | 295.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avatrombopag Impurity 38.
Avatrombopag Impurity 38 (CAS 2161380-87-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4BrClN2S2 and a molecular weight of 295.61 g/mol.
The molecular framework of Avatrombopag Impurity 38 (C7H4BrClN2S2) is characterized by a nitrile group, sulfur-containing functionality, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4BrClN2S2 |
| Molecular Weight | 295.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 43 (CAS 1268118-96-2)
- Avatrombopag Impurity 144 (CAS CATO-C4X-2234144)
- Avatrombopag impurity 125 (CAS CATO-C4X-2234125)
- Avatrombopag Impurity 18 (CAS 958457-83-5)
- Avatrombopag Impurity 72 (CAS CATO-C4X-223472)
- Avatrombopag Impurity 50 (CAS CATO-C4X-223450)
Recommended Standards
- 3-(4-Chloro-2-fluoro-5-methoxyphenyl)-5-(trifluoromethyl)isoxazole (CAS 653569-96-1)
- N-(2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)ethanamine (CAS 2096333-72-9)
- 3-(4-Chlorophenyl)-3-(2,2,2-trifluoroacetamido)propanoic acid (CAS 117291-25-5)
- 5-Bromo-4-chloro-2-(methylthio)thieno[2,3-d]pyrimidine (CAS 1823552-34-6)
- Pitavastatin Impurity 134 (CAS CATO-C4X-1037134)
- Decitabine Impurity 25 (CAS 1034301-08-0&1140891-02-6)
- Lifitegrast Impurity 142 (CAS 2098810-32-1)
- Pitavastatin Impurity 93 (CAS 254452-96-5(free base))
- 9-Octadecenoic acid, sodium salt, (9E)- (CAS 18175-45-6)
- 4-Methyl-1-penten-3-ol (CAS 4798-45-2)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
- 5-Pyridin-2-yl-1,3,4-oxadiazol-2-amine (CAS 5711-72-8)
- Carbidopa Impurity 15 (CAS 579-27-1)
- D-β-Asp15-Tirzepatide (CAS CATO-CPTD788930)
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