Avatrombopag Impurity 18 CAS 958457-83-5
| CAS No. | 958457-83-5 |
| Molecular Formula | C12H13ClN2O4 |
| Molecular Weight | 284.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Avatrombopag Impurity 18 (CAS 958457-83-5), a pharmacopoeial impurity reference standard (molecular formula C12H13ClN2O4, MW 284.70 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Avatrombopag Impurity 18 (C12H13ClN2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 284.70 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Avatrombopag Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H13ClN2O4 |
| Molecular Weight | 284.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 96 (CAS CATO-C4X-223496)
- Avatrombopag Impurity 144 (CAS CATO-C4X-2234144)
- Avatrombopag impurity 134 (CAS CATO-C4X-2234134)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 38 (CAS 2161380-87-4)
- Avatrombopag Impurity 43 (CAS 1268118-96-2)
- Avatrombopag impurity 125 (CAS CATO-C4X-2234125)
- Avatrombopag Impurity 52 (CAS 1224935-95-8)
Recommended Standards
- Apixaban Impurity 117 (CAS CATO-C4X-1088117)
- tert-Butyl 2-(chloromethyl)-5-fluoro-1H-benzo[d]imidazole-1-carboxylate (CAS 1002750-44-8)
- Erlotinib impurity 129 (CAS CATO-C4X-1069129)
- 2-Chloro-1-(4-(4-fluorobenzoyl)piperazin-1-yl)ethanone (CAS 1018525-90-0)
- Dotinurad Impurity 183 (CAS CATO-C4X-2494183)
- Desonide Impurity 10 (CAS CATO-C4X-130110)
- Noradrenaline Trifluoroacetate EP Impurity G (CAS 13062-58-3(Free Base))
- Methyl 5-amino-2-methyl-4-(methylamino)benzoate (CAS 863885-80-7)
- N-(6-bromoimidazo[1,2-a]pyridin-2-yl)acetamide (CAS 1162680-84-3)
- 1-(2-Bromo-5-fluorophenyl)propylamine (CAS 1270512-84-9)
- Sulfamerazine-13C6 (CAS 1196157-80-8)
- Ethyl 6-methoxybenzofuran-3-carboxylate (CAS 36748-74-0)
- Bis(N-propylsalicylideneaminato)nickel (CAS 15379-66-5)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com