Empagliflozin impurity 214 CAS 2819995-58-7
| CAS No. | 2819995-58-7 |
| Molecular Formula | C20H25ClO2Si |
| Molecular Weight | 360.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Empagliflozin impurity 214 (C20H25ClO2Si) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Empagliflozin impurity 214 (CAS 2819995-58-7) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25ClO2Si and a molecular weight of 360.95 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25ClO2Si |
| Molecular Weight | 360.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 145 (CAS CATO-C4X-1065145)
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 248 (CAS 143128-40-9)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- Empagliflozin impurity 22 (CAS CATO-C4X-1065322)
- Empagliflozin Impurity 45 (CAS CATO-C4X-106545)
Recommended Standards
- 18-Chloro-18-oxooctadecan-7-yl acetate (CAS 102376-29-4)
- N-(2,6-dibromo-4-(trifluoromethyl)phenyl)acetamide (CAS 544716-06-5)
- 2,6-Dibromo-4-(trifluoromethyl)phenyl isothiocyanate (CAS 1027512-32-8)
- SIFSIX-3-Ni (CAS 1801992-25-5)
- GST-HG171 Impurity 3 (CAS CATO-C4X-30603)
- Palonosetron Impurity 14 (CAS 177932-92-2)
- Afoxolaner impurity 8 (CAS CATO-C4X-31378)
- 3-(2,6-Dichlorophenyl)-3-hydroxypropanenitrile (CAS 868135-76-6)
- 1,5-Difluoronaphthalene (CAS 315-58-2)
- 2-Amino-6-(tert-butyl)-N-(furan-2-ylmethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (CAS 588678-81-3)
- (1-phenylbutyl)amine hydrochloride (CAS 91251-22-8)
- N-(1-benzothiophen-3-ylmethyl)aminosulfonamide (CAS 877316-38-6)
- 4-(Chloromethyl)-2-(methoxymethyl)pyrimidine (CAS 1341507-67-2)
- [D-Ser6]-Semaglutide (CAS CATO-C4X-2226287)
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